Contact person: Professor Lo
Persson, phone: +46-(0)46-2227746
The Faculty of Medicine at Lund University has been reorganised.
The Division of Molecular and
Cellular Physiology is now part of the Department of Experimental
Medical Science. The researchers here utilise molecular biological and
cell physiological techniques to explore the signal transduction in general
and in specialised cell types. The staff consists of three full professors,
four post-doctoral fellows, 12 research students and 3 technical assistants
divided on three independent groups; one of which is on Polyamines,
and is led by
Lo Persson and co-workers.
Research connected to South Asia:
Persson was involved in a major project on ”Structure-based
drug development against malaria and leishmaniasis”,
in collaboration with research groups headed by Salam
Al-Karadaghi, Dept of Molecular
Biophysics, Lund University; Olle
Heby, Dept of Molecular Biology,
Umeå University; and Rentala
Madhubala, at the School
of Life Sciences, Jawaharlal Nehru University (JNU), New Delhi, India.
In November 2002 this project was given a Swedish Research
Links (Asian–Swedish research partnership programme) grant on 375
000 SEK for three years (2003-05) by Sida and the Swedish Research Council.
See the full list of South Asia related projects
that were given grants.
In November 2005 the project got a one-year extension to complete the Swedish
Research Links project. More information. Project description:
This Indo-Swedish co-operation project deals with basic research on certain
enzymes prevalent in parasites which cause Malaria and Leishmaniasis (both
diseases common in India). The research might result in development of
new drugs against these diseases which infect humans living in rural areas
of many developing countries, and constitute a major health problem. Estimately
300 to 500 million people are infected around the world. The available
chemotherapeutic agents against these diseases are still of relatively
low potency and/or high toxicity, and despite much effort very few highly
effective drugs have been developed in recent years.
Inhibitors of polyamine biosynthesis exhibit promising effects against
other parasitic diseases. With the present project, new approaches involving
structure-based drug design and molecular modeling are initiated, aiming
at prevention and intervention of leishmaniasis and malaria. Possibilities
will be explored that polyamine biosynthetic enzymes and transporters
can be inhibited as part of an overall chemotherapeutic strategy, and
that the transporters can be deluded to carry toxic polyamine analogs
into the parasites.
The project is now compeleted, and no current South Asia related research is carried out within the department (Oct. 2008).